WormBase (www.wormbase.org) is an ever-expanding repository of genetic, genomic, and biological information for C. elegans (and other closely related nematodes).

This talk will highlight some of the new datasets that have been added recently to WormBase, detail some of the new features available on the website, and discuss upcoming features.

Among large-scale datasets incorporated into WormBase in the past year are: the complete genome sequence of C. briggsae with comparative analyses against C. elegans; protein interactions; 3-D structural data; systematic gene knockouts; engineered transposon insertions; and serial analysis of gene expression (SAGE) tags.

Ongoing literature curation efforts continue to incorporate data of finer granularity into the database. These efforts have been expanded to include genetic interactions; detailed allelic information including sequences and phenotypes; the assignment of controlled vocabulary terms for gene function, anatomy, and sequences; and reagents such as antibodies.

Of significant note, WormBase plans to add the complete genomes and comparative analyses of three related Caenorhabditis species over the coming year. These species include C. remanei, C. japonica, and CB5161.

WormBase exists to serve the C. elegans and broader biomedical community, and the WormBase Consortium thanks our many data contributors and collaborators, especially those providing their large-scale datasets, and those providing feedback. Comments, questions and suggestions are always welcome and can be made by emailing wormbase-help@wormbase.org.